Enhancer detection in zebrafish permits the identification of neuronal subtypes that express Hox4 paralogs.

@article{Punnamoottil2008EnhancerDI,
  title={Enhancer detection in zebrafish permits the identification of neuronal subtypes that express Hox4 paralogs.},
  author={Beena Punnamoottil and Hiroshi Kikuta and Guillaume P{\'e}zeron and Jelena Erceg and Thomas S. Becker and Silke Rinkwitz},
  journal={Developmental dynamics : an official publication of the American Association of Anatomists},
  year={2008},
  volume={237 8},
  pages={
          2195-208
        }
}
Activity of zebrafish hoxb4a in the developing brain was analyzed in comparison to hoxa4a and hoxd4a using unique enhancer detection transgenes. Cytoplasmic YFP revealed shape and axonal projections of neurons in animals with insertions near the Hox4 genes and provided a means for the identification of neuronal subtypes. Despite an early activity of the genes in neuroepithelial cells and later in immature postmitotic neurons, we found reporter expression in distinct neuronal subtypes in the r7… CONTINUE READING
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