Enhancer cooperativity as a novel mechanism underlying the transcriptional regulation of E-cadherin during mesenchymal to epithelial transition.

Abstract

Epithelial-mesenchymal transition (EMT) and mesenchymal-epithelial transition (MET) highlight crucial steps during embryogenesis and tumorigenesis. Induction of dramatic changes in gene expression and cell features is reflected by modulation of Cdh1 (E-cadherin) expression. We show that Cdh1 activity during MET is governed by two enhancers at +7.8 kb and at… (More)
DOI: 10.1016/j.bbagrm.2015.01.005

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@article{Alotaibi2015EnhancerCA, title={Enhancer cooperativity as a novel mechanism underlying the transcriptional regulation of E-cadherin during mesenchymal to epithelial transition.}, author={Hani Alotaibi and Maria Felicia Basilicata and Huma Shehwana and Tyler Kosowan and Ilona Schreck and Christien Braeutigam and Ozlen Konu and Thomas Brabletz and Marc P Stemmler}, journal={Biochimica et biophysica acta}, year={2015}, volume={1849 6}, pages={731-42} }