Enhancer competition between H19 and Igf2 does not mediate their imprinting.

  title={Enhancer competition between H19 and Igf2 does not mediate their imprinting.},
  author={Jennifer V Schmidt and John M. Levorse and Shirley M. Tilghman},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={96 17},
The linked H19 and Igf2 genes on mouse distal chromosome 7 are subject to genomic imprinting. Competition between the promoters of the genes for transcription from shared enhancers has been proposed as an explanation for the coordinate expression and reciprocal imprinting of these two genes. To test this model, we have used Cre-loxP technology to generate in mice a conditional deletion of the H19 promoter and structural gene that leaves no transcription unit in the locus. Contrary to the… CONTINUE READING


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