Enhancer–core-promoter specificity separates developmental and housekeeping gene regulation

@article{Zabidi2015EnhancercorepromoterSS,
  title={Enhancer–core-promoter specificity separates developmental and housekeeping gene regulation},
  author={Muhammad Munim Ahmad Zabidi and Cosmas D. Arnold and Katharina Schernhuber and Michaela Pagani and Martina Rath and Olga Frank and Alexander Stark},
  journal={Nature},
  year={2015},
  volume={518},
  pages={556-559}
}
Gene transcription in animals involves the assembly of RNA polymerase II at core promoters and its cell-type-specific activation by enhancers that can be located more distally. However, how ubiquitous expression of housekeeping genes is achieved has been less clear. In particular, it is unknown whether ubiquitously active enhancers exist and how developmental and housekeeping gene regulation is separated. An attractive hypothesis is that different core promoters might exhibit an intrinsic… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 92 times. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 79 extracted citations

Similar Papers

Loading similar papers…