Enhancement techniques for improving 5aminolevulinic 5aminolevulinic 5aminolevulinic acid delivery through the skin

@inproceedings{ZhangEnhancementTF,
  title={Enhancement techniques for improving 5aminolevulinic 5aminolevulinic 5aminolevulinic acid delivery through the skin},
  author={Li-wen Zhang and Yi-Ping Fang and Jia-You Fang}
}
Photodynamic therapy (PDT) is a popular technique for skin cancer treatment. Protoporphyrin IX, which is a photosensitizing agent, converted enzymatically from the prodrug 5-aminolevulinic acid (ALA), is used as a photosensitizer in PDT for cancer. However, ALA penetrates with difficulty through intact skin; therefore, improving delivery systems for ALA in the skin will play an important role in ALA-PDT. Enhancement of ALA skin penetration can be achieved by physical methods, such as… CONTINUE READING

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