Enhancement of wound healing by curcumin in animals

  title={Enhancement of wound healing by curcumin in animals},
  author={Gurmel S. Sidhu and Ashutosh Kumar Singh and Deepa Thaloor and Krishna K Banaudha and Gyanendra K. Patnaik and Rikhab Chand Srimal and Radha K. Maheshwari},
  journal={Wound Repair and Regeneration},
Tissue repair and wound healing are complex processes that involve inflammation, granulation, and remodeling of the tissue. In this study, we evaluated the in vivo effects of curcumin (difeurloylmethane), a natural product obtained from the rhizomes of Curcuma longa on wound healing in rats and guinea pigs. We observed faster wound closure of punch wounds in curcumin‐treated animals in comparison with untreated controls. Biopsies of the wound showed reepithelialization of the epidermis and… 
Curcumin enhances wound healing in streptozotocin induced diabetic rats and genetically diabetic mice
  • G. Sidhu, H. Mani, R. Maheshwari
  • Biology, Medicine
    Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society
  • 1999
Results show that curcumin enhanced wound repair in diabetic impaired healing, and could be developed as a pharmacological agent in such clinical settings.
Curcumin improves wound healing by modulating collagen and decreasing reactive oxygen species
Curcumin treated wounds were found to heal much faster as indicated by improved rates of epithelialisation, wound contraction and increased tensile strength which were also confirmed by histopathological examinations.
Curcumin-induced angiogenesis hastens wound healing in diabetic rats.
Sustained wound healing activity of curcumin loaded oleic acid based polymeric bandage in a rat model.
Western blotting and semiquantitative PCR analysis clearly indicate that COP bandage can efficiently quench free radicals leading to reduced antioxidative enzyme activity and indicates that such a versatile approach may seed new arena for topical wound healing in the near future.
Curcumin Enhanced Cutaneous Wound Healing by Modulating Cytokines and Transforming Growth Factor in Excision Wound Model in Rats
Cutaneous wounds are physical injuries that result in an opening or break of the skin that causes disturbances in the normal skin anatomy & function (Strodtbeck, 2001). It is an orchestrated series
Wound healing activity of curcumin conjugated to hyaluronic acid: in vitro and in vivo evaluation
Wound healing efficacy studied in diabetic mice demonstrated that topical application of the conjugate on wounds led to better healing as compared to treatment with HA-free curcumin and HA alone, suggesting that HA conjugation is a promising formulation ofCurcumin for enhancing its healing efficacy.
The effects of topical treatment with curcumin on burn wound healing in rats
Results clearly substantiate the beneficial effects of the topical application of Cur in the acceleration of wound healing and indicate that there is a rise in the expression of proliferating cell nuclear antigen in skin tissues of Cur-treated rats in the Burn group.
Wound‐healing potential of curcumin in the carp, Labeo rohita
It could be concluded that dietary administration of curcumin is beneficial in rapid healing of skin wounds in fish and could be considered to prevent the invasion of pathogens and to maintain the integrity of the surrounding tissue.
Curcumin differentially regulates TGF‐β1, its receptors and nitric oxide synthase during impaired wound healing
The study indicates an enhancement in dexamethasone impaired wound repair by topical curcumin and its differential regulatory effect on TGF‐β1, it's receptors and iNOS in this cutaneous wound‐healing model.


Enhanced wound healing in animal models by interferon and an interferon inducer
It is suggested that Poly I:C and IFN treatment result in a faster restoration of tissue integrity in both full skin punch biopsy and skin incision models.
Accelerated healing of incisional wounds in rats induced by transforming growth factor-beta.
TGF-beta is a potent pharmacologic agent that can accelerate wound healing in rats and is accompanied by an increased influx of mononuclear cells and fibroblasts and by marked increases in collagen deposition at the site of application of TGF- beta.
Growth factor-induced acceleration of tissue repair through direct and inductive activities in a rabbit dermal ulcer model.
The results establish that polypeptide growth factors have significant and selective positive influences on healing of full thickness ulcers in the rabbit.
PDGF and TGF-α Act Synergistically to Improve Wound Healing in the Genetically Diabetic Mouse
The PDGF-BB/TGF-alpha combination accelerated healing in the diabetic animals to a rate that was closer to that seen in nondiabetic mice.
The role of extracellular matrix in postinflammatory wound healing and fibrosis
  • R. Raghow
  • Biology
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 1994
Current known mechanisms by which extracellular matrix modulates different facets of the process of tissue remodeling after injury, which culminate either in normal wound repair or fibrosis, are discussed.
The biology of the myofibroblast. Relationship to wound contraction and fibrocontractive diseases
Wound healing consists schematically of acute inflammation followed by formation of granulation tissue, a transitional tissue able to retract the wound space, and finally scar formation.
Transforming Growth Factor-ill Induces u-Smooth Muscle Actin Expression in Granulation Tissue Myofibroblasts and in Quiescent and Growing Cultured Fibroblasts
It is shown that the subcutaneous administration of transforming growth factor-ill to rats results in the formation of a granulation tissue in which a-SM actin expressing myofibroblasts are particularly abundant, and suggests that TGFfll plays an important role in my ofibroblast differentiation during wound healing and fibrocontractive diseases.
Fibronectin in healing rabbit corneal wounds.
Findings are compatible with the hypothesis that fibronectin and fibrin play a role in epithelial migration and temporary adhesion to the surface during corneal wound healing, at a time when the normal anchoring mechanism is lost.
Alpha-smooth muscle actin is transiently expressed by myofibroblasts during experimental wound healing.
It is concluded that myofibroblasts develop gradually from granulation tissue fibroblast and temporarily express a marker of smooth muscle differentiation, which may be relevant for the understanding of the mechanisms of normal and pathologic wound healing.
Quantitative analysis of stress fiber orientation during corneal wound contraction.
The spatial and temporal organization of stress fibers during the process of corneal wound healing is analyzed to suggest that stress fibers undergo temporal changes in spatial organization that correlate with wound closure, and that wound closure does not involve the development of previously described contractile or tractional forces aligned directly across the wound.