Enhancement of voltage-gated K+ channels and depression of voltage-gated Ca2+ channels are involved in quercetin-induced vasorelaxation in rat coronary artery.

  title={Enhancement of voltage-gated K+ channels and depression of voltage-gated Ca2+ channels are involved in quercetin-induced vasorelaxation in rat coronary artery.},
  author={Xiaomin Hou and Yu Liu and Longgang Niu and Lijuan Cui and Mingsheng Zhang},
  journal={Planta medica},
  volume={80 6},
Quercetin is one of the most common flavonoids in the human daily diet. Its affects the coronary artery, especially L-type voltage-gated Ca2+ channels and voltage-gated K+ channels in the arterial smooth muscle cells, which are poorly understood. The present experiments were designed to study the myogenic effect of quercetin and its possible underlying mechanisms in the rat coronary artery. A wire myograph was used to observe the myogenic effects. Arterial smooth muscle cells were freshly… 
Extracellular acidosis contracts coronary but neither renal nor mesenteric artery via modulation of H+,K+‐ATPase, voltage‐gated K+ channels and L‐type Ca2+ channels
This report is the first to demonstrate that extracellular acidosis alkalinizes the cytosol of arterial smooth muscle cells freshly isolated from rat coronary artery and contracts the artery exclusively and to suggest that modulation of voltage‐gated K+ channels, voltage‐ gated Ca2+ channels and H+,K+‐ATPase are involved in the contraction.
Quercetin depletes intracellular Ca2+ stores and blunts ATP‐triggered Ca2+ signaling in bEnd.3 endothelial cells
For the first time, quercetin perturbed intracellular Ca2+ stores and strongly suppressed ATP‐triggered response in bEnd.3 EC, and raised cytosolic Ca2-level in a concentration‐dependent manner.
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