Enhancement of viral transformation for evaluation of the carcinogenic or mutagenic potential of inorganic metal salts.

@article{Casto1979EnhancementOV,
  title={Enhancement of viral transformation for evaluation of the carcinogenic or mutagenic potential of inorganic metal salts.},
  author={Bruce Cordell Casto and Joel D Meyers and Joseph A Dipaolo},
  journal={Cancer research},
  year={1979},
  volume={39 1},
  pages={193-8}
}
Thirty-eight metal salts were tested for their capacity to enhance transformation of Syrian hamster embryo cells by a simian adenovirus, SA7. All of the metal salts with known carcinogenic potential in animals or mutagenic activity in microbial or mammalian cells increased the SA7 transformation frequency. Metals were classified into three groups according to the concentration necessary to produce significant enhancement. Those showing highest activity (positive at less than 0.05 mM) were the… CONTINUE READING
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