Enhancement of vincristine cytotoxicity in drug-resistant cells by simultaneous treatment with onconase, an antitumor ribonuclease.

@article{Rybak1996EnhancementOV,
  title={Enhancement of vincristine cytotoxicity in drug-resistant cells by simultaneous treatment with onconase, an antitumor ribonuclease.},
  author={Susanna M. Rybak and John W. Pearson and William E. Fogler and Kirk M. Volker and Sally E. Spence and Dianne L. Newton and S. M. Mikulski and Wojciech Ardelt and Charles W. Riggs and Hank F Kung and Dan L. Longo},
  journal={Journal of the National Cancer Institute},
  year={1996},
  volume={88 11},
  pages={747-53}
}
BACKGROUND Onconase, a protein isolated from oocytes and early embryos of the frog Rana pipiens, shares extensive homology with bovine pancreatic ribonuclease (RNase A) and possesses similar enzyme activity. Onconase is cytotoxic toward cancer cells in vitro and exhibits antitumor activity in animal models. In addition, Onconase has been shown to enhance the cytotoxic activity of some chemotherapeutic agents in vitro. PURPOSE We studied interactions between the cytotoxic effects of Onconase… CONTINUE READING