Enhancement of vaccine-induced primary and memory CD8(+) T-cell responses by soluble PD-1.

@article{Song2011EnhancementOV,
  title={Enhancement of vaccine-induced primary and memory CD8(+) T-cell responses by soluble PD-1.},
  author={Mi-Young Song and Seongjae Park and Hyo Jung Nam and Dong-Hoon Choi and Young Chul Sung},
  journal={Journal of immunotherapy},
  year={2011},
  volume={34 3},
  pages={
          297-306
        }
}
Programmed death 1 (PD-1) signaling through its ligands, PD-L1 and PD-L2, has been known to negatively regulate T-cell responses. In addition, PD-L1 has been shown to interact with B7-1 costimulatory molecule to inhibit T-cell responses. Extensive studies have shown that PD-1/PD-L blockade restores exhausted T cells during chronic viral infections and tumors. In this study, we evaluated the effects of soluble PD-1 (sPD-1) as a blockade of PD-1 and PD-L1 on vaccine-elicited antigen-specific T… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 33 CITATIONS

Soluble PD-1 and PD-L1: predictive and prognostic significance in cancer

  • Oncotarget
  • 2017
VIEW 4 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED