Enhancement of tumor necrosis factor-alpha gene expression by low doses of prostaglandin E2 and cyclic GMP.

@article{Gong1990EnhancementOT,
  title={Enhancement of tumor necrosis factor-alpha gene expression by low doses of prostaglandin E2 and cyclic GMP.},
  author={Jinmei Gong and Harald Renz and Harald Sprenger and Marianne Nain and Diethard Gemsa},
  journal={Immunobiology},
  year={1990},
  volume={182 1},
  pages={
          44-55
        }
}
Macrophage-derived PGE2 is usually considered to be a down-regulator of TNF-alpha production. However, we recently demonstrated that PGE2 may display dual activities in that low concentrations stimulated whereas higher doses suppressed TNF-alpha synthesis in resident peritoneal macrophages. To examine the underlying molecular mechanisms, we studied TNF-alpha gene expression in rat peritoneal macrophages and the murine PU5-1.8 macrophage line. In both macrophage types, PGE2 enhanced TNF-alpha… CONTINUE READING
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