Enhancement of tumor growth and vascular density by transfection of vascular endothelial cell growth factor into MCF-7 human breast carcinoma cells.

@article{Zhang1995EnhancementOT,
  title={Enhancement of tumor growth and vascular density by transfection of vascular endothelial cell growth factor into MCF-7 human breast carcinoma cells.},
  author={H T Zhang and Paul Craft and Prudence A E Scott and Marina Ziche and Herbert A. Weich and Al Harris and Roy Bicknell},
  journal={Journal of the National Cancer Institute},
  year={1995},
  volume={87 3},
  pages={213-9}
}
BACKGROUND Vascular endothelial growth factor (VEGF) is a secreted endothelial-specific growth factor that is angiogenic in vivo. It is commonly expressed in a range of carcinomas. PURPOSE The study was designed to investigate the effect of constitutive expression of VEGF on tumor formation by estrogen-dependent human MCF-7 breast carcinoma cells. METHODS A full-length complementary DNA encoding the shortest isoform of VEGF (VEGF121) was stably transfected into MCF-7 cells. Transfected… CONTINUE READING

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