Enhancement of trinitrophenyl-specific humoral response to TNP proteins as the result of carrier chlorination.

Abstract

Trinitrophenyl (TNP)-specific humoral response was tested after immunization with TNP-protein conjugates composed of either native proteins or proteins modified by chlorination. Significant enhancement of the hapten-specific response was observed as a result of carrier chlorination. This effect was dose dependent and affected mainly T-helper-cell activation. Since stimulated neutrophils chlorinate in vivo proteins, we propose that they take part in the induction phase of immune response by facilitation of antigen processing and/or presentation.

Cite this paper

@article{Marcinkiewicz1992EnhancementOT, title={Enhancement of trinitrophenyl-specific humoral response to TNP proteins as the result of carrier chlorination.}, author={Janusz Marcinkiewicz and Ewa Olszowska and Sławomir Olszowski and J M Zgliczyński}, journal={Immunology}, year={1992}, volume={76 3}, pages={385-8} }