Enhancement of translation elongation in neurons by brain-derived neurotrophic factor: implications for mammalian target of rapamycin signaling.

@article{Inamura2005EnhancementOT,
  title={Enhancement of translation elongation in neurons by brain-derived neurotrophic factor: implications for mammalian target of rapamycin signaling.},
  author={Naoko Inamura and Hiroyuki Nawa and Nobuyuki Takei},
  journal={Journal of neurochemistry},
  year={2005},
  volume={95 5},
  pages={
          1438-45
        }
}
The effects and signaling mechanisms of brain-derived neurotrophic factor (BDNF) on translation elongation were investigated in cortical neurons. BDNF increased the elongation rate approximately twofold, as determined by measuring the ribosomal transit time. BDNF-accelerated elongation was inhibited by rapamycin, implicating the mammalian target of rapamycin (mTOR). To explore the mechanisms underlying these effects, we examined the protein phosphorylation cascades that lead to the activation… CONTINUE READING