Enhancement of toxicity of anticholinesterases by central depressant drugs in rats.

@article{Weiss1967EnhancementOT,
  title={Enhancement of toxicity of anticholinesterases by central depressant drugs in rats.},
  author={L R Weiss and R A Orzel},
  journal={Toxicology and applied pharmacology},
  year={1967},
  volume={10 2},
  pages={
          334-9
        }
}
Abstract The possibility that central-depressant drugs in general enhance the acute toxicity of anticholinesterases in rats was studied. The pesticides, carbaryl and parathion, were administered parenterally to animals pretreated with chlorpromazine, meprobamate, reserpine, chlordiazepoxide, hexobarbital, phenobarbital, and alcohol. Comparisons were made between carbaryl and carbaryl-drug combinations and between parathion and parathion-drug combinations, using mortality as an index of toxicity… CONTINUE READING