Enhancement of the tumor penetration of monoclonal antibody by fusion of a neuropilin-targeting peptide improves the antitumor efficacy.

@article{Shin2014EnhancementOT,
  title={Enhancement of the tumor penetration of monoclonal antibody by fusion of a neuropilin-targeting peptide improves the antitumor efficacy.},
  author={Tae-Hwan Shin and Eun-Sil Sung and Ye-Jin Kim and Ki-Su Kim and Se-Ho Kim and Seok Ki Kim and Young-Don Lee and Yong-Sung Kim},
  journal={Molecular cancer therapeutics},
  year={2014},
  volume={13 3},
  pages={651-61}
}
The limited localization and penetration of monoclonal antibodies (mAb) into solid tumors restricts their antitumor efficacy. Here, we describe a solid tumor-targeting antibody with enhanced tumor penetration activity. We designed a 22-residue peptide (A22p), which was extracted from the C-terminal basic region of semaphorin 3A (Sema3A) but modified to have higher affinity with neuropilin receptors (NRP), and genetically fused it to the C-terminus of Fc of human immunoglobulin G1 via a 15… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 41 references

Neuropilins: expression and roles in the epithelium.

International journal of experimental pathology • 2012
View 5 Excerpts
Highly Influenced

C-end rule peptides mediate neuropilin-1-dependent cell, vascular, and tissue penetration.

Proceedings of the National Academy of Sciences of the United States of America • 2009
View 4 Excerpts
Highly Influenced

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