Enhancement of the rate of spontaneous mutation to 6-thioguanine resistance in mammalian cells by polyamine depletion.


Several lines of evidence have suggested, but not proved, that polyamines are associated with DNA in intact cells. In an attempt to investigate the roles of polyamines in gene-associated functions, we examined the effects of polyamine depletion on the spontaneous mutation rate in a rat basophilic leukemia cell line. The frequency of 6-thioguanine-resistant… (More)


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