Enhancement of the chemoprotective enzymes glucuronosyl transferase and glutathione transferase in specific organs of the rat by the coffee components kahweol and cafestol

@article{Huber2002EnhancementOT,
  title={Enhancement of the chemoprotective enzymes glucuronosyl transferase and glutathione transferase in specific organs of the rat by the coffee components kahweol and cafestol},
  author={Wolfgang W. Huber and Sonja Prustomersky and Evert H. Delbanco and Maria Uhl and Gerlinde Scharf and Robert J Turesky and Ricarda Thier and Rolf Schulte-Hermann},
  journal={Archives of Toxicology},
  year={2002},
  volume={76},
  pages={209-217}
}
The coffee components kahweol and cafestol (K/C) have been reported to protect the colon and other organs of the rat against the formation of DNA adducts by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) and aflatoxin B1. PhIP is a cooked-food mutagen to which significant human exposure and a role in colon cancer etiology are attributed, and, interestingly, such cancers appear to develop at a lower rate in consumers of coffees with high amounts of K/C. Earlier studies in rodent liver… CONTINUE READING
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