Enhancement of the biologic effects of interleukin-3 in vivo by anti-interleukin-3 antibodies.

@article{Jones1993EnhancementOT,
  title={Enhancement of the biologic effects of interleukin-3 in vivo by anti-interleukin-3 antibodies.},
  author={Anthony T. Jones and Hermann J. Ziltener},
  journal={Blood},
  year={1993},
  volume={82 4},
  pages={1133-41}
}
Interleukin-3 (IL-3) has been shown to be a promising agent in the stimulation of bone marrow regeneration following myeloablative therapy. The biologic half-life of this agent is very short (5 to 15 minutes), which limits the effectiveness of low-dose therapy. Here we show that the biologic effects of low-dose IL-3 in mice may be enhanced by concurrent use of polyclonal anti-IL-3 antibodies. The biologic effects of IL-3 in vivo were enhanced dramatically by the combination of the cytokine and… CONTINUE READING

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