Enhancement of the bioavailability of cinnarizine from its beta-cyclodextrin complex on oral administration with L-isoleucine as a competing agent.

@article{Tokumura1986EnhancementOT,
  title={Enhancement of the bioavailability of cinnarizine from its beta-cyclodextrin complex on oral administration with L-isoleucine as a competing agent.},
  author={Tadakazu Tokumura and Yuki Tsushima and Kimio Tatsuishi and Masanori Kayano and Yoshiharu Machida and Tsuneji Nagai},
  journal={Chemical \& pharmaceutical bulletin},
  year={1986},
  volume={34 3},
  pages={
          1275-9
        }
}
This investigation was aimed at the improvement of the bioavailability of cinnarizine (CN) by administering its β-cyclodextrin (β-CD) complex together with a competing agent. The ability of L-leucine (L-Leu) and L-isoleucine (L-Ileu) to act as competing agents was evaluated by determining the penetration rate of CN, employing a Sartorius absorption simulator. L-Ileu showed a stronger competing action than L-Leu. The bioavailability of CN, upon oral administration of the CN-β-CD inclusion… 
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