Enhancement of the antitumor activity of 5-fluorouracil by drug combinations.

@article{Frankfurt1973EnhancementOT,
  title={Enhancement of the antitumor activity of 5-fluorouracil by drug combinations.},
  author={Oskar S. Frankfurt},
  journal={Cancer research},
  year={1973},
  volume={33 5},
  pages={
          1043-7
        }
}
We planned the treatment of Ehrlich ascites tumor, taking into account the duration of cell-cycle phases and their sensitivity to various drugs. Two days after the inoculation of 107 ascites tumor cells, mice were given one injection of different drug combinations and the tumor cell number was then counted. It was found that hydroxyurea enhanced the antitumor activity of 5-fluorouracil (5-FU). This effect was evident only when 5-FU was injected together with vinblastine or when 5-FU was… CONTINUE READING

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