Enhancement of the antidepressant action of fluoxetine by folic acid: a randomised, placebo controlled trial.


BACKGROUND A consistent finding in major depression has been a low plasma and red cell folate which has also been linked to poor response to antidepressants. The present investigation was designed to investigate whether the co-administration of folic acid would enhance the antidepressant action of fluoxetine. METHODS 127 patients were randomly assigned to… (More)


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