Enhancement of the anti-tumor activity of therapeutic monoclonal antibodies by CXCR4 antagonists

@article{Hu2012EnhancementOT,
  title={Enhancement of the anti-tumor activity of therapeutic monoclonal antibodies by CXCR4 antagonists},
  author={Yanping Hu and M. Gale and J. Shields and Carrie Garron and M. Swistak and T. Nguyen and G. Jacques and Robert Fogle and W. Siders and J. Kaplan},
  journal={Leukemia \& Lymphoma},
  year={2012},
  volume={53},
  pages={130 - 138}
}
Abstract The interaction between CXCR4 on the surface of tumor cells and CXCL12 in the stroma is believed to contribute to tumor cell survival and protection against drug treatment. Inhibition of stromal survival signals by CXCR4 antagonists has been reported to render tumor cells more sensitive to chemotherapy, but little is known about potential synergy with monoclonal antibodies. In this study, administration of the small molecule CXCR4 antagonists plerixafor and GENZ-644494 was found to… Expand
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