Enhancement of the Antitumor Effect of Methotrexate on Colorectal Cancer Cells via Lactate Calcium Salt Targeting Methionine Metabolism

@article{Jo2017EnhancementOT,
  title={Enhancement of the Antitumor Effect of Methotrexate on Colorectal Cancer Cells via Lactate Calcium Salt Targeting Methionine Metabolism},
  author={Young-kwon Jo and M. Park and Hyunju Choi and H. Lee and Jong-Moon Park and Jae Jun Sim and Chonghwan Chang and Keun-Yeong Jeong and H. Kim},
  journal={Nutrition and Cancer},
  year={2017},
  volume={69},
  pages={663 - 673}
}
  • Young-kwon Jo, M. Park, +6 authors H. Kim
  • Published 2017
  • Medicine, Chemistry
  • Nutrition and Cancer
  • ABSTRACT Methionine (Met) is involved in one-carbon de novo nucleotide synthesis and is an essential amino acid for cell survival. The impact of lactate calcium salt (CaLa) on the Met metabolism was investigated to evaluate the enhanced antitumor effect of methotrexate (MTX) on colorectal cancer (CRC) cells. Met dependency relating to homocysteine (Hcy) and betaine was investigated in human CRC cells (HCT-116 and HT-29) using a viability assay and liquid chromatography-mass spectrometry… CONTINUE READING

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