Enhancement of systemic tumor immunity for squamous cell carcinoma cells by an oncolytic herpes simplex virus

@article{Meshii2013EnhancementOS,
  title={Enhancement of systemic tumor immunity for squamous cell carcinoma cells by an oncolytic herpes simplex virus},
  author={Noritoshi Meshii and Gen Takahashi and Shusuke Okunaga and Masakazu Hamada and Soichi Iwai and Ayako Takasu and Youichi Ogawa and Yoshiaki Yura},
  journal={Cancer Gene Therapy},
  year={2013},
  volume={20},
  pages={493-498}
}
RH2 is a neurovirulent γ134.5 gene-deficient herpes simplex virus type 1 (HSV-1) with a lytic ability in human squamous cell carcinoma (SCC) cells; it is related to spontaneously occurring HSV-1 mutant HF10. The effect of RH2 on SCC was examined using a syngeneic C3H mouse model. After infection of mouse SCCVII cells with RH2, cell viability was decreased at first, but recovered by prolonged culture, indicating the limited replication of RH2. The antitumor ability of RH2 was examined using a… CONTINUE READING
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