Enhancement of stromal cell-derived factor-1alpha-induced chemotaxis for CD4/8 double-positive thymocytes by fibronectin and laminin in mice.

@article{Yanagawa2001EnhancementOS,
  title={Enhancement of stromal cell-derived factor-1alpha-induced chemotaxis for CD4/8 double-positive thymocytes by fibronectin and laminin in mice.},
  author={Yoshiki Yanagawa and Kazuya Iwabuchi and Kazunori On{\'o}e},
  journal={Immunology},
  year={2001},
  volume={104 1},
  pages={43-9}
}
Stromal cell-derived factor-1alpha (SDF-1alpha) is a chemokine abundantly expressed in the thymus. However, a potential role of SDF-1alpha in the thymus has been under consideration, since no appreciable difference was detected in the migratory responsiveness to the SDF-1alpha between cortical and medullary thymocytes. In the present study, we examined the effects of extracellular matrix (ECM) on the responsiveness of murine thymocytes to several chemokines including SDF-1alpha. In the absence… CONTINUE READING

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