Enhancement of skin-flap survival using nitroglycerin ointment.

  title={Enhancement of skin-flap survival using nitroglycerin ointment.},
  author={Rod J. Rohrich and George W. Cherry and Melvin Spira},
  journal={Plastic and reconstructive surgery},
  volume={73 6},
Rat and pig skin flaps were used to investigate the effects of topical nitroglycerin ointment on flap survival. Significant increase in flap survival was detected and correlated well with plasma nitroglycerin levels measured during the treatment regimen. The drug was applied 1 hour preoperatively in both models. Recent experimental clinical investigations… CONTINUE READING