Enhancement of seed phytosterol levels by expression of an N-terminal truncated Hevea brasiliensis (rubber tree) 3-hydroxy-3-methylglutaryl-CoA reductase.

@article{Harker2003EnhancementOS,
  title={Enhancement of seed phytosterol levels by expression of an N-terminal truncated Hevea brasiliensis (rubber tree) 3-hydroxy-3-methylglutaryl-CoA reductase.},
  author={Mark Harker and Niklas Holmberg and John C. Clayton and Carl L Gibbard and Andrew D. Wallace and Sally Rawlins and Susan Amanda Hellyer and Alexandra Lanot and Richard Bedford Safford},
  journal={Plant biotechnology journal},
  year={2003},
  volume={1 2},
  pages={
          113-21
        }
}
Dietary intake of phytosterols (plant sterols) has been shown to be effective in reducing blood cholesterol levels, thereby reducing the risk of cardiovascular disease. Phytosterols are most commonly sourced from vegetable oils, where they are present as minor components. We report here the generation of transgenic tobacco seeds substantially enhanced in phytosterol content by the expression of a modified form of one of the key sterol biosynthetic enzymes, 3-hydroxy-3-methylglutaryl-CoA… CONTINUE READING
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