Enhancement of replication of genetically engineered herpes simplex viruses by ionizing radiation: a new paradigm for destruction of therapeutically intractable tumors

@article{Advani1998EnhancementOR,
  title={Enhancement of replication of genetically engineered herpes simplex viruses by ionizing radiation: a new paradigm for destruction of therapeutically intractable tumors},
  author={S K Advani and G Sibley and P Song and D. P. Hallahan and Yasufumi Kataoka and Bernard Roizman and RR Weichselbaum},
  journal={Gene Therapy},
  year={1998},
  volume={5},
  pages={160-165}
}
Human U-87 malignant glioma xenografts in mice were exposed to ionizing radiation, inoculated with a herpes simplex virus 1 mutant R3616 lacking both copies of the γ134.5 gene, or received both virus and radiation. Dual treatment caused a significantly greater reduction in volume or total regression of tumors than either radiation or infection alone. The significantly enhanced oncolytic effects of the combined treatment correlate with two- to five-fold enhanced replication in irradiated tumor… CONTINUE READING
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