Enhancement of radiation damage in cellular DNA following unifilar substitution with iododeoxyuridine.

Abstract

The exact mechanism of x-ray radiosensitization with iododeoxyuridine (IdUrd) is not known. Using log phase V79 cells, we compared radiosensitization following unifilar (9 hr exposure) and bifilar (17 hr exposure) substitution with 10(-5) M IdUrd. The % thymidine replacement was 8% and 16%, respectively. Significant radiosensitization was found with… (More)

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