Enhancement of quinone redox cycling by ascorbate induces a caspase-3 independent cell death in human leukaemia cells. An in vitro comparative study.

@article{Verrax2005EnhancementOQ,
  title={Enhancement of quinone redox cycling by ascorbate induces a caspase-3 independent cell death in human leukaemia cells. An in vitro comparative study.},
  author={Julien Verrax and Marianne Delvaux and Nelson Beghein and Henryk S. Taper and Bernard Gallez and Pedro Buc Calderon},
  journal={Free radical research},
  year={2005},
  volume={39 6},
  pages={
          649-57
        }
}
Since the higher redox potential of quinone molecules has been correlated with enhanced cellular deleterious effects, we studied the ability of the association of ascorbate with several quinones derivatives (having different redox potentials) to cause cell death in K562 human leukaemia cell line. The rationale is that the reduction of quinone by ascorbate should be dependent of the quinone half-redox potential thus determining if reactive oxygen species (ROS) are formed or not, leading… CONTINUE READING
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