Enhancement of procollagen biosynthesis by p180 through augmented ribosome association on the endoplasmic reticulum in response to stimulated secretion.

@article{Ueno2010EnhancementOP,
  title={Enhancement of procollagen biosynthesis by p180 through augmented ribosome association on the endoplasmic reticulum in response to stimulated secretion.},
  author={Tomonori Ueno and Keisuke Tanaka and Keiko Kaneko and Yuki Taga and Tetsutaro Sata and Shinkichi Irie and Shunji Hattori and Kiyoko Ogawa-Goto},
  journal={The Journal of biological chemistry},
  year={2010},
  volume={285 39},
  pages={29941-50}
}
A coiled-coil microtubule-bundling protein, p180, was originally reported as a ribosome-binding protein on the rough endoplasmic reticulum (ER) and is highly expressed in secretory tissues. Recently, we reported a novel role for p180 in the trans-Golgi network (TGN) expansion following stimulated collagen secretion. Here, we show that p180 plays a key role in procollagen biosynthesis and secretion in diploid fibroblasts. Depletion of p180 caused marked reductions of secreted collagens without… CONTINUE READING
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