• Biology, Medicine
  • Published in Molecular cancer therapeutics 2003

Enhancement of platinum-induced cytotoxicity by O6-benzylguanine.

@article{Fishel2003EnhancementOP,
  title={Enhancement of platinum-induced cytotoxicity by O6-benzylguanine.},
  author={Melissa L Fishel and Shannon M. Delaney and Lindsay D Friesen and Ryan John Hansen and Eleanor G. Zuhowski and Robert C. Moschel and Merrill J. Egorin and M. Eileen Dolan},
  journal={Molecular cancer therapeutics},
  year={2003},
  volume={2 7},
  pages={
          633-40
        }
}
O(6)-Benzylguanine (O(6)-BG), a potent inactivator of the DNA repair protein O(6)-alkylguanine-DNA alkyltransferase (AGT), is presently in clinical trials combined with alkylating agents that modify the O(6) position of DNA guanine residues, i.e., 1,3-bis(2-chloroethyl)-1-nitrosourea and temozolomide. Previous work demonstrated that O(6)-BG also enhances the cytotoxicity of cyclophosphamide, ifosfamide, and nitrogen mustards in Chinese hamster ovary cells. We have extended this study to include… CONTINUE READING

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