Enhancement of plasminogen activation by surfactin C: augmentation of fibrinolysis in vitro and in vivo.

  title={Enhancement of plasminogen activation by surfactin C: augmentation of fibrinolysis in vitro and in vivo.},
  author={T. Kikuchi and K. Hasumi},
  journal={Biochimica et biophysica acta},
  volume={1596 2},
  • T. Kikuchi, K. Hasumi
  • Published 2002
  • Chemistry, Medicine
  • Biochimica et biophysica acta
  • The reciprocal activation of plasminogen and prourokinase (pro-u-PA) is an important mechanism in the initiation and propagation of local fibrinolytic activity. We have found that a bacterial lipopeptide compound, surfactin C (3-20 microM), enhances the activation of pro-u-PA in the presence of plasminogen. This effect accompanied increased conversions of both pro-u-PA and plasminogen to their two-chain forms. Surfactin C also elevated the rate of plasminogen activation by two-chain urokinase… CONTINUE READING
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