Enhancement of plasminogen activation by surfactin C: augmentation of fibrinolysis in vitro and in vivo.

@article{Kikuchi2002EnhancementOP,
  title={Enhancement of plasminogen activation by surfactin C: augmentation of fibrinolysis in vitro and in vivo.},
  author={T. Kikuchi and K. Hasumi},
  journal={Biochimica et biophysica acta},
  year={2002},
  volume={1596 2},
  pages={
          234-45
        }
}
  • T. Kikuchi, K. Hasumi
  • Published 2002
  • Chemistry, Medicine
  • Biochimica et biophysica acta
  • The reciprocal activation of plasminogen and prourokinase (pro-u-PA) is an important mechanism in the initiation and propagation of local fibrinolytic activity. We have found that a bacterial lipopeptide compound, surfactin C (3-20 microM), enhances the activation of pro-u-PA in the presence of plasminogen. This effect accompanied increased conversions of both pro-u-PA and plasminogen to their two-chain forms. Surfactin C also elevated the rate of plasminogen activation by two-chain urokinase… CONTINUE READING
    59 Citations
    Glucosyldiacylglycerol Enhances Reciprocal Activation of Prourokinase and Plasminogen
    • 6
    Surfactin C inhibits platelet aggregation
    • 25
    Mechanism of the action of SMTP-7, a novel small-molecule modulator of plasminogen activation
    • 7
    Stachybotrydial Selectively Enhances Fibrin Binding and Activation of Glu-plasminogen
    • 6
    • PDF
    The anti-thrombotic activity of surfactins.
    • 24
    • PDF
    Inhibition of Lipopolysaccharide Activity by a Bacterial Cyclic Lipopeptide Surfactin
    • 34
    • PDF

    References

    SHOWING 1-10 OF 31 REFERENCES
    Activation of plasminogen by pro-urokinase. I. Mechanism.
    • 168
    • PDF
    Enhancement of plasminogen binding to U937 cells and fibrin by complestatin.
    • 25
    The plasminogen (fibrinolytic) system.
    • D. Collen
    • Medicine
    • Thrombosis and haemostasis
    • 1999
    • 417
    The cell biology of the plasminogen system
    • 411