Enhancement of outward potassium current may participate in beta-amyloid peptide-induced cortical neuronal death.

@article{Yu1998EnhancementOO,
  title={Enhancement of outward potassium current may participate in beta-amyloid peptide-induced cortical neuronal death.},
  author={Shan Ping Yu and Z S Farhangrazi and Howard S. Ying and C. H. Yeh and Dennis W. Choi},
  journal={Neurobiology of disease},
  year={1998},
  volume={5 2},
  pages={81-8}
}
In light of recent evidence implicating the upregulation of outward K+ current in mediating several forms of neuronal apoptosis, we tested the hypothesis that such an upregulation might specifically contribute to the pathogenesis of beta-amyloid peptide (A beta)-induced neuronal death. Exposure to A beta fragment 25-35 (20 microM) or 1-42 (20 microM) enhanced the delayed rectifier K+ current IK, shifting its activation voltage relationship toward hyperpolarized levels and increasing maximal… CONTINUE READING