Enhancement of oral bioavailability of fenofibrate by solid self-microemulsifying drug delivery systems.

@article{Kim2013EnhancementOO,
  title={Enhancement of oral bioavailability of fenofibrate by solid self-microemulsifying drug delivery systems.},
  author={Gun Gook Kim and Bijay Kumar Poudel and Nirmal Marasini and Dong Won Lee and Tran Tuan Hiep and Kwan Yeol Yang and Jong Oh Kim and Chul Soon Yong and Han-gon Choi},
  journal={Drug development and industrial pharmacy},
  year={2013},
  volume={39 9},
  pages={1431-8}
}
A solid form of self-microemulsifying drug delivery system (Solid SMEDDS) was developed by spray-drying with dextran as the inert solid carrier, to improve the oral bioavailability of a poorly water-soluble drug, fenofibrate. The optimized liquid SMEDDS, composed of Labrafil M 1944 CS/Labrasol/Capryol PGMC (15/75/10%v/v) with 10% w/v fenofibrate gave a z-average diameter of around 240 nm. There was no significant difference in the mean droplet size and size distribution of the emulsions… CONTINUE READING

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