Enhancement of opiate analgesia by nimodipine in cancer patients chronically treated with morphine: a preliminary report

@article{Santilln1994EnhancementOO,
  title={Enhancement of opiate analgesia by nimodipine in cancer patients chronically treated with morphine: a preliminary report},
  author={Rosa Santill{\'a}n and J.M. Maestre and Mar{\'i}a A. Hurl{\'e} and Jes{\'u}s Fl{\'o}rez},
  journal={Pain},
  year={1994},
  volume={58},
  pages={129-132}
}
Adjuncts to opioid therapy
  • F. Goldstein
  • Medicine
    The Journal of the American Osteopathic Association
  • 2002
TLDR
Inadequate analgesia can become a suicidogen, ie, any factor that causes a patient to want to commit suicide, when patients are likely to request physicians to provide some method to accelerate their death.
The Influence of Three L-Type Calcium Channel Blockers on Morphine Effects in Healthy Volunteers
TLDR
Results are at odds with numerous animal studies and several clinical studies, which indicate that calcium channel blockers of the L-type increase the amount of analgesia produced by morphine, and using clinically relevant doses of L- type blockers could find no potentiation of morphine analgesia.
Phase II, open-label, multicenter study of combined intrathecal morphine and ziconotide: addition of ziconotide in patients receiving intrathecal morphine for severe chronic pain.
TLDR
Ziconotide, combined with stable intrathecal morphine, may reduce pain and decrease systemic opioid use in patients with pain inadequately controlled by intratheCal morphine alone.
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It was concluded that nimodipine but not nifedipine administration can reduce fentanyl requirements during surgical procedures without influencing the quality of anaesthesia.
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The data indicate that Ca2+ is important in mediating the analgesic effects of opiates and suggest that calcium-receptor blockers might find a place in the treatment of pain.
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The modulatory effect of continued activation of opiate receptors with agonist on the receptor level was examined in current studies and it was observed that, 3 days after etorphine treatment, there was a decrease in mu opioid receptor binding, with minimal change in delta opioid receptors binding in both brain regions of striatum and midbrain.
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The individual and combined effects of subcutaneous morphine and diltiazem, a calcium channel inhibitor, on arterial blood gases and pH were assessed in conscious Fischer‐344 rats. Morphine (4mg
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