Enhancement of opiate analgesia by nimodipine in cancer patients chronically treated with morphine: a preliminary report

  title={Enhancement of opiate analgesia by nimodipine in cancer patients chronically treated with morphine: a preliminary report},
  author={Rosa Santill{\'a}n and J.M. Maestre and Mar{\'i}a A. Hurl{\'e} and Jes{\'u}s Fl{\'o}rez},
Adjuncts to opioid therapy
  • F. Goldstein
  • Medicine
    The Journal of the American Osteopathic Association
  • 2002
Inadequate analgesia can become a suicidogen, ie, any factor that causes a patient to want to commit suicide, when patients are likely to request physicians to provide some method to accelerate their death.
The Influence of Three L-Type Calcium Channel Blockers on Morphine Effects in Healthy Volunteers
Results are at odds with numerous animal studies and several clinical studies, which indicate that calcium channel blockers of the L-type increase the amount of analgesia produced by morphine, and using clinically relevant doses of L- type blockers could find no potentiation of morphine analgesia.
Phase II, open-label, multicenter study of combined intrathecal morphine and ziconotide: addition of ziconotide in patients receiving intrathecal morphine for severe chronic pain.
Ziconotide, combined with stable intrathecal morphine, may reduce pain and decrease systemic opioid use in patients with pain inadequately controlled by intratheCal morphine alone.


Low-dose fentanyl analgesia modified by calcium channel blockers in cardiac surgery.
It was concluded that nimodipine but not nifedipine administration can reduce fentanyl requirements during surgical procedures without influencing the quality of anaesthesia.
Effect of Nifedipine on Morphine‐Induced Analgesia
The data indicate that Ca2+ is important in mediating the analgesic effects of opiates and suggest that calcium-receptor blockers might find a place in the treatment of pain.
Interaction of morphine with intrathecally administered calcium and calcium antagonists: evidence for supraspinal endogenous opioid mediation of intrathecal calcium-induced antinociception in mice.
Calcium may serve as a useful adjunct for opioid-induced analgesia via the i.p.t. and i.c.v. routes.
Decrease in delta and mu opioid receptor binding capacity in rat brain after chronic etorphine treatment.
  • P. TaoP. LawH. Loh
  • Biology, Medicine
    The Journal of pharmacology and experimental therapeutics
  • 1987
The modulatory effect of continued activation of opiate receptors with agonist on the receptor level was examined in current studies and it was observed that, 3 days after etorphine treatment, there was a decrease in mu opioid receptor binding, with minimal change in delta opioid receptors binding in both brain regions of striatum and midbrain.
Analgesic effects of several calcium channel blockers in mice.
Effects of diltiazem on morphine‐induced respiratory decline
The individual and combined effects of subcutaneous morphine and diltiazem, a calcium channel inhibitor, on arterial blood gases and pH were assessed in conscious Fischer‐344 rats. Morphine (4mg