Enhancement of opiate analgesia by nimodipine in cancer patients chronically treated with morphine: a preliminary report

@article{Santilln1994EnhancementOO,
  title={Enhancement of opiate analgesia by nimodipine in cancer patients chronically treated with morphine: a preliminary report},
  author={R. Santill{\'a}n and J. Maestre and M. Hurl{\'e} and J. Fl{\'o}rez},
  journal={Pain},
  year={1994},
  volume={58},
  pages={129-132}
}
The ability of nimodipine, a calcium-channel blocker, to enhance morphine analgesia and/or modify the development of tolerance was studied in patients with cancer pain who had needed successive increments of morphine for periods ranging from 21 to 780 days. Assessment of daily morphine consumption was the primary effect parameter. Nimodipine succeeded in reducing the daily dose of morphine in 16 of 23 patients (oral, n = 13; intrathecal, n = 3), and failed to modify it in 2 patients. Total oral… Expand
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