Enhancement of noradrenaline release by 12-O-tetradecanoyl phorbol-13-acetate, an activator of protein kinase C.

@article{Allgaier1986EnhancementON,
  title={Enhancement of noradrenaline release by 12-O-tetradecanoyl phorbol-13-acetate, an activator of protein kinase C.},
  author={Clemens Allgaier and O Von K{\"u}gelgen and Georg Hertting},
  journal={European journal of pharmacology},
  year={1986},
  volume={129 3},
  pages={389-92}
}
12-O-Tetradecanoyl phorbol-13-acetate (TPA), an activator of protein kinase C (PKC), enhanced the electrically evoked overflow of [3H]noradrenaline in a concentration-dependent manner in rabbit hippocampal slices. 4-O-Methyl-TPA, which lacks the ability to activate PKC had no effect on the evoked tritium overflow. The enhancement of noradrenaline release by TPA was affected by neither the alpha 2-adrenoceptor antagonist yohimbine nor the alpha 2-adrenoceptor agonist clonidine. It is concluded… CONTINUE READING

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