Enhancement of natural cytotoxicity by beta-endorphin.

  title={Enhancement of natural cytotoxicity by beta-endorphin.},
  author={Paul M. Mathews and Christopher J. Froelich and Wilmer L Sibbitt and Arthur D. Bankhurst},
  journal={Journal of immunology},
  volume={130 4},
The role of enkephalins, beta-endorphin, or other neuropeptides produced by the nervous system in the alteration of immune responsiveness is generally unknown. The present studies were undertaken to investigate the role of these neuropeptides in the modulation of human spontaneous cytotoxicity induced by natural killer (NK) cells. Natural cytotoxicity was measured by using a standard 51Cr release assay with radiolabeled K562 cells. NK activity was significantly enhanced by both beta-endorphin… CONTINUE READING
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