Enhancement of mucosal immune responses by chimeric influenza HA/SHIV virus-like particles.

@article{Yao2003EnhancementOM,
  title={Enhancement of mucosal immune responses by chimeric influenza HA/SHIV virus-like particles.},
  author={Qing’an Yao},
  journal={Research initiative, treatment action : RITA},
  year={2003},
  volume={8 2},
  pages={
          20-1
        }
}
To enhance mucosal immune responses using simian-human immunodeficiency virus-like particles (SHIV VLPs) as a mucosal HIV vaccine, we have produced phenotypically mixed, chimeric influenza HA/SHIV 89.6 VLPs and used them to immunize C57B/6J mice intranasally. Systemic and mucosal antibody responses, as well as cytotoxic T cell (CTL) responses, were compared in groups immunized with SHIV 89.6 VLPs or HA/SHIV 89.6 VLPs. Intranasal immunizations were given using VLPs either with or without the… CONTINUE READING
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