Enhancement of mitochondrial biogenesis and paradoxical inhibition of lactate dehydrogenase mediated by 14-3-3η in oncocytomas.

@article{Feng2018EnhancementOM,
  title={Enhancement of mitochondrial biogenesis and paradoxical inhibition of lactate dehydrogenase mediated by 14-3-3η in oncocytomas.},
  author={Jie Feng and Qi Zhang and Chuzhong Li and Yang Zhou and Sida Zhao and Lichuan Hong and Qi Song and Shenyuan Yu and Chunxiu Hu and Herui Wang and Chengyuan Mao and Matthew J. Shepard and Shuyu Hao and Gifty A Dominah and Mitchell Sun and Hanping Wan and Deric M. Park and Mark R. Gilbert and Guowang Xu and Zhengping Zhuang and Yazhuo Zhang},
  journal={The Journal of pathology},
  year={2018},
  volume={245 3},
  pages={
          361-372
        }
}
Oncocytomas represent a subset of benign pituitary adenomas that are characterized by significant mitochondrial hyperplasia. Mitochondria are key organelles for energy generation and metabolic intermediate production for biosynthesis in tumour cells, so understanding the mechanism underlying mitochondrial biogenesis and its impact on cellular metabolism in oncocytoma is vital. Here, we studied surgically resected pituitary oncocytomas by using multi-omic analyses. Whole-exome sequencing did not… CONTINUE READING
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