Enhancement of mast cell survival: a novel function of some secretory phospholipase A(2) isotypes.

@article{Fonteh2001EnhancementOM,
  title={Enhancement of mast cell survival: a novel function of some secretory phospholipase A(2) isotypes.},
  author={Alfred N. Fonteh and Chad R Marion and Brooke J. Barham and Michelle B. Edens and Gen-ichi Atsumi and James M. Samet and Kevin P. High and Floyd H. Chilton},
  journal={Journal of immunology},
  year={2001},
  volume={167 8},
  pages={4161-71}
}
This study tested the hypothesis that certain secretory phospholipase A(2) (sPLA(2)) isotypes act in a cytokine-like fashion through cell surface receptors to influence mast cell survival. Initial experiments revealed that sPLA(2) activity and sPLA(2) receptor expression are increased, and mast cells lost their capacity to maintain membrane asymmetry upon cytokine depletion. Groups IB and III, but not group IIA PLA(2), prevented the loss of membrane asymmetry. Similarly, group IB prevented… CONTINUE READING

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