Enhancement of macrophage phagocytosis upon iC3b deposition on apoptotic cells.

@article{Takizawa1996EnhancementOM,
  title={Enhancement of macrophage phagocytosis upon iC3b deposition on apoptotic cells.},
  author={Fumio Takizawa and Shotaro Tsuji and Shigeharu Nagasawa},
  journal={FEBS letters},
  year={1996},
  volume={397 2-3},
  pages={269-72}
}
Apoptotic cells activate homologous complement and are opsonized with iC3b. We assessed the effect of iC3b opsonization upon phagocytosis of apoptotic Jurkat cells by macrophages, which were differentiated from THP-1 cells by treatment with retinoic acid. Macrophage phagocytosis of apoptotic Jurkat cells was enhanced upon incubation of the apoptotic cells with normal human serum. The enhanced macrophage phagocytosis of normal serum-treated apoptotic cells was decreased by anti-human C3 F(ab')2… CONTINUE READING

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