Enhancement of long-term spatial memory in adult rats by the noncompetitive NMDA receptor antagonists, memantine and neramexane.

@article{Zoladz2006EnhancementOL,
  title={Enhancement of long-term spatial memory in adult rats by the noncompetitive NMDA receptor antagonists, memantine and neramexane.},
  author={Phillip R Zoladz and Adam Marc Campbell and Collin R. Park and Daniela Schaefer and Wojciech Danysz and David M. Diamond},
  journal={Pharmacology, biochemistry, and behavior},
  year={2006},
  volume={85 2},
  pages={298-306}
}
Memantine and neramexane are noncompetitive NMDA receptor antagonists which have been investigated for their promising effects in aiding memory in people with dementia. Memantine is approved for the treatment of Alzheimer's disease, and neramexane is currently under development for this indication. Therefore, the present study provided a comparative assessment of the effects of equimolar doses of memantine and neramexane on spatial (hippocampus-dependent) memory. Adult male rats were given only… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 1 time. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 40 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 71 references

Low doses of memantine disrupt memory in adult rats.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2006
View 5 Excerpts
Highly Influenced

Memantine improves spatial learning in a transgenic mouse model of Alzheimer's disease.

The Journal of pharmacology and experimental therapeutics • 2004
View 4 Excerpts
Highly Influenced

The metabotropic glutamate receptors: structure, activation mechanism and pharmacology.

Current drug targets. CNS and neurological disorders • 2002
View 2 Excerpts
Highly Influenced

LTP mechanisms: from silence to four-lane traffic.

Current opinion in neurobiology • 2000
View 13 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…