Enhancement of long-term spatial memory in adult rats by the noncompetitive NMDA receptor antagonists, memantine and neramexane

@article{Zoladz2006EnhancementOL,
  title={Enhancement of long-term spatial memory in adult rats by the noncompetitive NMDA receptor antagonists, memantine and neramexane},
  author={P. Zoladz and A. Campbell and Collin R. Park and D. Schaefer and W. Danysz and D. Diamond},
  journal={Pharmacology Biochemistry and Behavior},
  year={2006},
  volume={85},
  pages={298-306}
}
Memantine and neramexane are noncompetitive NMDA receptor antagonists which have been investigated for their promising effects in aiding memory in people with dementia. Memantine is approved for the treatment of Alzheimer's disease, and neramexane is currently under development for this indication. Therefore, the present study provided a comparative assessment of the effects of equimolar doses of memantine and neramexane on spatial (hippocampus-dependent) memory. Adult male rats were given only… Expand
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