Enhancement of lipopolysaccharide-stimulated PGE2 and IL-1beta production in gingival fibroblast cells from old rats.


The effect of aging on gingival fibroblasts in response to bacterial infection was studied. Rat gingival fibroblast (rGF) cells were cultured from gingival tissue removed from young (6 weeks old) and old (20 months old) rats. Both types of rGF cells were challenged with lipopolysaccharide (LPS) from the periodontal pathogen Campylobacter rectus. The levels… (More)


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