Enhancement of in vivo adenovirus-mediated gene transfer and expression by prior depletion of tissue macrophages in the target organ.

@article{Wolff1997EnhancementOI,
  title={Enhancement of in vivo adenovirus-mediated gene transfer and expression by prior depletion of tissue macrophages in the target organ.},
  author={Gerhard Wolff and Stefan Worgall and Nico Van Rooijen and Wen-chao Song and B G Harvey and Ronald G. Crystal},
  journal={Journal of virology},
  year={1997},
  volume={71 1},
  pages={624-9}
}
Based on the hypothesis that tissue macrophages present an obstacle for adenovirus (Ad) vector-mediated gene transfer to internal organs, this study evaluated the consequences of transient depletion of Kupffer cells on subsequent transfer of the Ad vector genome and Ad vector-directed gene expression in the livers of experimental animals. Depletion of Kupffer cells in mice by intravenous administration of multilamellar liposomes containing dichloromethylene-bisphosphonate permitted subsequent… CONTINUE READING

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