Enhancement of immunogenicity of a virosome-based avian influenza vaccine in chickens by incorporating CpG-ODN.

@article{Mallick2011EnhancementOI,
  title={Enhancement of immunogenicity of a virosome-based avian influenza vaccine in chickens by incorporating CpG-ODN.},
  author={Amirul Islam Mallick and Payvand Parvizi and Leah R. Read and {\'E}va {\'E} Nagy and Shahriar Behboudi and Shayan Sharif},
  journal={Vaccine},
  year={2011},
  volume={29 8},
  pages={1657-65}
}
Influenza virosomes are virus-like particles, representing a platform for vaccine development. In this study, we examined the immunogenicity of avian influenza virosomes with or without inclusion of recombinant chicken interferon-gamma (rChIFN-γ) or CpG-ODN in chickens. Immunization with virosomes adjuvanted with CpG-ODN elicited the highest haemagglutination inhibition antibody titres, as well as IgG and IgA serum antibody responses. Moreover, Virosomes+CpG-ODN formulation induced an antigen… CONTINUE READING
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