Corpus ID: 24285509

Enhancement of immune responses to neem leaf extract (Azadirachta indica) correlates with antineoplastic activity in BALB/c-mice.

  title={Enhancement of immune responses to neem leaf extract (Azadirachta indica) correlates with antineoplastic activity in BALB/c-mice.},
  author={J. Beuth and H. Schneider and H. Ko},
  journal={In vivo},
  volume={20 2},
An aqueous plant extract from Azadirachta indica and its chromatographic fraction F1 (neem extract) exerted immunomodulating and antimetastatic activities in BALB/ c-mice. Regular subcutaneous administration of neem extract yielded significantly increased spleen weight and significant enhancement of peritoneal macrophage activity in the chemiluminescence assay, and activation marker CD-44 expression. The thymus weight and thymocyte counts did not show significant differences in the control and… Expand
Neem components as potential agents for cancer prevention and treatment.
The anti-proliferative and apoptosis-inducing effects of neem components are tumor selective as the effects on normal cells are significantly weaker, and neem extracts sensitize cancer cells to immunotherapy and radiotherapy, and enhance the efficacy of certain cancer chemotherapeutic agents. Expand
Neem leaf glycoprotein is nontoxic to physiological functions of Swiss mice and Sprague Dawley rats: histological, biochemical and immunological perspectives.
Accumulated evidence strongly suggests the non-toxic nature of NLGP, which can be recommended for human use in anti-cancer therapy and induces proliferation of mononuclear cells collected from mice and rats. Expand
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Azadirachta indica A. Juss. (Meliaceae)
A fast-growing, evergreen tree, native to the Indian subcontinent, India, Pakistan, Myanmar, Nepal, Bangladesh, Sri Lanka, and Maldives, widely cultivated in Africa, and in southern part of Iran, butExpand
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ML I can be regarded as a potent immunomodulating and antimetastatic substance, which seems to be promising for clinical trials in human oncology. Expand
Modulation of humoral and cell-mediated immune responses by Azadirachta indica (Neem) in mice.
The effects of A. indica (AI, Neem) were evaluated on tests of humoral and cell-mediated immune responses after 3 weeks of oral AI (leaf extract) treatment in ovalbumin immunized mice and there was an enhancement of macrophage migration inhibition, and footpad thickness after AI (100 mg/kg) treatment. Expand
Thymocyte proliferation and maturation in response to galactoside-specific mistletoe lectin-1.
Administration of ML-1 accelerated murine thymocyte proliferation and maturation in BALB/c-mice after regular subcutaneous administration of the optimal immunomodulating dosage (1ng lectin/kg body weight) and induced a potent immunostimulation. Expand
Ethanolic leaf extract of neem (Azadirachta indica) inhibits buccal pouch carcinogenesis in hamsters
It is demonstrated that ethanolic neem leaf extract inhibits the development of DMBA‐induced HBP tumours by protecting against oxidative stress. Expand
Possible mechanism of antiinflammatory activity of Azadirachta indica leaf extract
The result suggests that A.indica extract's antiinflammatory effect may be due to antagonism of the deleterious effect of 5-HT and PGE1 on blood vessels. Expand
Antifertility Effects of Aqueous and Steroidal Extracts of Neem Leaf (Azadirachta indica) in Male Wistar Rats
The antifertility efficacy of both aqueous and steroidal extracts of neem (Azadirachta indica A. Juss) leaves was studied in male Wistar rats, with a decline in the fertility index. Expand
Digestive tract microflora liberates low molecular weight peptides with immunotriggering activity.
Antibiotic digestive tract decontamination in BALB/c-mice resulted in a significant reduction of peritoneal macrophage function and lymphocyte proliferation and substitution of peptides in GI-tract decontaminated mice reconstituted macrophages function as well as proliferation of lymphatic tissue. Expand
Blocking of lectin-like adhesion molecules on pulmonary cells inhibits lung sarcoma L-1 colonization in BALB/c-mice
When lectin-like adhesion molecules on pulmonary cells were blocked with competitive glycoconjugates, tumor cell colonization of the lung could be significantly inhibited. Expand
Factor affecting the in vitro assessment of opsonization: a study of the kinetics of opsonization using the technique of phagocytic chemiluminescence.
The importance of several factors involved in the investigation of opsonic defects was studied using phagocytic Luminol-dependent chemiluminescence and results were compared with those using other methods and were found to correlate well. Expand
Early T lymphocytes. Differentiation in vivo of adult intrathymic precursor cells
The findings suggest that the isolated dLy-1 thymocytes described herein are precursor thymocyte that represent a very early stage in intrathymic development. Expand