Enhancement of immune response of HBsAg loaded poly (L-lactic acid) microspheres against hepatitis B through incorporation of alum and chitosan.

@article{Pandit2007EnhancementOI,
  title={Enhancement of immune response of HBsAg loaded poly (L-lactic acid) microspheres against hepatitis B through incorporation of alum and chitosan.},
  author={Sreenivas Pandit and Erdal Cevher and Mohammed Gulrez Zariwala and Satyanarayana Somavarapu and H Oya Alpar},
  journal={Journal of microencapsulation},
  year={2007},
  volume={24 6},
  pages={539-52}
}
PURPOSE Poly (L-lactic acid) (PLA) microparticles encapsulating Hepatitis B surface antigen (HBsAg) with alum and chitosan were investigated for their potential as a vaccine delivery system. METHODS The microparticles, prepared using a water-in-oil-in-water (w/o/w) double emulsion solvent evaporation method with polyvinyl alcohol (PVA) or chitosan as the external phase stabilising agent showed a significant increase in the encapsulation efficiency of the antigen. RESULTS PLA-Alum and PLA… CONTINUE READING