Enhancement of hydrogen peroxide-induced luminol-dependent chemiluminescence by neopterin depends on the presence of iron chelator complexes.

@article{Murr1994EnhancementOH,
  title={Enhancement of hydrogen peroxide-induced luminol-dependent chemiluminescence by neopterin depends on the presence of iron chelator complexes.},
  author={Christian Murr and Dietmar Fuchs and Walter Goessler and Asno Hausen and Gilbert Reibnegger and Ernst R Werner and G Werner-felmayer and Harald Esterbauer and Helmut Wachter},
  journal={FEBS letters},
  year={1994},
  volume={338 2},
  pages={223-6}
}
We have previously shown that neopterin, 6-D-erythro-trihydroxypropyl-pteridine, synthesized by human monocytes/macrophages upon stimulation by interferon-gamma, enhances toxicity of reactive oxygen at neutral or slightly alkaline pH (7.5), but not at acidic pH (below 6.5). In the present study, we explored in more detail the necessary requirements for… CONTINUE READING